Gene(s) Tested Effect ACC2 Reduced response to insulin ADCY5 Inhibited secretion of insulin FABP2, FTO Increased uptake of saturated fats ADIPOQ, CRY2, FADS1, G6PC2, GLUT2, MTNR1B, PROX1, TCF7L2 Increased fasting glucose levels GCKR Reduced fasting glucose levels GCK, HNF4A Reduced pancreatic beta cell function GLIS3, IRS1, SLC30A8 Disrupted insulin production/signalling/storage SHBG Increased sex hormone binding globulin MADD Impaired proinsulin-to-insulin conversion SOD2 Increased reactive oxygen species HIF1A Resistance to hypoxia

How many diabetes risk factors do you have? Genetic variation Family history of type 2 diabetes Obesity and fat accumulation (around the abdomen) Lack of physical exercise Ethnicity (Africans and American Indians have a higher risk) Prediabetes – elevated blood sugar Gestational diabetes Polycystic ovarian syndrome

Type 2 Diabetes Risk DNA Test

Does diabetes run in your family?
Take this DNA test to understand your genetic risk for type 2 diabetes.

Includes variants that influence glucose levels, fat metabolism, insulin production and response to insulin
70% chance of developing type 2 diabetes when both parents have the disease
Private and confidential online results
Painless sample collection

Collection method: Buccal swab

$349.00

Detailed Description

Type 2 diabetes is a metabolic disorder that disrupts the body’s normal glucose and insulin balance. It is generally associated with unhealthy lifestyles and extra body weight, but genetic variations can also increase your risk, regardless of your lifestyle.

Glucose is the primary source of energy used by the cells in our bodies. The levels of this simple sugar are regulated by the hormone insulin, produced by the beta cells of the pancreas. People with type 2 diabetes do not make sufficient amounts of insulin, therefore have consistently high blood sugar levels.

With a simple mouth swab you can find out whether you have inherited DNA changes that increase your risk of type 2 diabetes.

The Genetics

Genetic variations can affect our glucose and insulin levels, sensitivity to dietary fatty acids, and the way our body responds to insulin, resulting in increased risk of type 2 diabetes. Knowledge of genetic variants that increase your risk of type 2 diabetes allows you to make lifestyle changes today, to reduce your risk of this debilitating condition.

Variants Tested

Gene(s) Tested	Effect
ACC2	Reduced response to insulin
ADCY5	Inhibited secretion of insulin
FABP2, FTO	Increased uptake of saturated fats
ADIPOQ, CRY2, FADS1, G6PC2, GLUT2, MTNR1B, PROX1, TCF7L2	Increased fasting glucose levels
GCKR	Reduced fasting glucose levels
GCK, HNF4A	Reduced pancreatic beta cell function
GLIS3, IRS1, SLC30A8	Disrupted insulin production/signalling/storage
SHBG	Increased sex hormone binding globulin
MADD	Impaired proinsulin-to-insulin conversion
SOD2	Increased reactive oxygen species
HIF1A	Resistance to hypoxia

Discover More

How many diabetes risk factors do you have?

Genetic variation
Family history of type 2 diabetes
Obesity and fat accumulation (around the abdomen)
Lack of physical exercise
Ethnicity (Africans and American Indians have a higher risk)
Prediabetes – elevated blood sugar
Gestational diabetes
Polycystic ovarian syndrome

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How it works

Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online